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KMID : 0387720160270010012
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Korean Journal of Blood Transfusion
2016 Volume.27 No. 1 p.12 ~ p.21
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Actual Incidence of Transfusion-Related Adverse Reactions Compared with Transfusion-Related Signs or Symptoms and by Each Blood Product
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류근영:Ryu Keun-Young
임채승:Lim Chae-Seung/고영은:Koh Young-Eun/윤정:Yoon Jeong/정보경:Jung Bo-Kyeung/김지용:Kim Jee-Yong/장미애:Jang Mi-Ae
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Abstract
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Background: Transfusion-related adverse reaction is detected based on patients’ adverse signs or symptoms during or after transfusion. We analyzed the actual incidence of transfusion-related adverse reactions by investigating diagnosed cases among reported signs or symptoms, and reexamined our transfusion-related adverse reaction reporting system.
Methods: From January to June, 2015, there were 4,234 cases of transfusion and 18,191 units of blood product were used. During transfusion, patients’ signs or symptoms were checked and reported by the medical team at least three times, 5 minutes after transfusion started, during transfusion, and after transfusion, using the electronic reporting system in the blood bank. A laboratory medicine doctor investigated reported signs or symptoms by reviewing patients’ electronic medical records, diagnosed transfusion-related adverse reaction by textbook definition, and surveyed actual incidence. In addition, incidence of transfusion-related signs or symptoms and transfusion- related adverse reaction by each blood product was determined.
Results: Out of 1,091 transfusion-related signs or symptoms, only 226 cases (20.71%) were diagnosed with transfusion-related adverse reaction. Among these, most common cases were febrile nonhemolytic reaction with incidence of 0.91%, followed by allergic reaction with 0.32%. The incidence of transfusion-related adverse reaction by each blood product was highest for leukocyte-reduced red blood cells 3.41% and apheresis platelets 2.59%. Febrile nonhemolytic reaction was mainly related to red blood cells and allergic reaction was mainly related to platelets.
Conclusion: The actual incidence of transfusion-related adverse reaction was only 20% of transfusion-related signs or symptoms. Therefore, reforming the reporting system and transfusion-related clinical inspection and education are required.
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KEYWORD
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Transfusion, Transfusion-related adverse reaction, Reporting system
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